Sedating antihistamines in
These newer antihistamines, on the market since the 1980s, appear to have little risk of being abused or causing addiction.
This is because they have little or no effect on the CNS.
Based on the review in the The risk of addiction is especially greater for people who are susceptible to drug abuse.
According to a report of a patient in the Journal of Child and Adolescent Psychopharmacology in 2010, DPH is abused for its sedative, sleep-inducing, and euphoric effects on the central nervous system.
The antihistamines cause addiction by increasing dopamine release in the brain's reward and pleasure centers, typical of addictive substances such as Vicodin and heroin.
Secondary scratching not only intensifies pruritus (the “itch-scratch cycle”) but also further compromises the skin barrier. Hannuksela M, Kalimo K, Lammintausta K, Mattila T, Turjanmaa K, Varjonen E, et al.
Oral antihistamines have been utilized in the management of pruritus in AD patients in an effort to improve their quality of life by inhibiting these vascular and neurologic effects, but there is insufficient evidence to recommend the general use of antihistamines as part of the treatment of AD. An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis. Dose ranging study: cetirizine in the treatment of atopic dermatitis in adults. There are numerous randomized, controlled trials that have examined whether systemic antihistamines benefit AD as a disease process, and whether their effects specifically benefit AD patients via itch relief.